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The handle http://hdl.handle.net/1887/29017 holds various files of this Leiden University
Author: Wijsman, Carolien A.
Title: Glucose metabolism in healthy ageing
Issue Date: 2014-10-08
Glucose metabolism
in healthy ageing
Carolien A. Wijsman
Glucose metabolism
in healthy ageing
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van de Rector Magnificus prof. mr. C.J.J.M. Stolker
volgens besluit van het College voor Promoties
te verdedigen op woensdag 8 oktober 2014
klokke 16.15 uur
ISBN: 978-90-9028405-7
Carolien A. Wijsman
© 2014 C.A. Wijsman
Copyright of each chapter is with the publisher of the journal in which the work has
geboren 20 april 1983
appeared. No part of this thesis may be reproduced, stored in a retrieval system or
te Den Haag
transmitted in any form or by any means, without permission of the author or,
when appropriate, of the publisher of publications.
Design & layout: M. Odijk
Printed by: SMG Groep
This research was performed within the framework of the Netherland Consortium for
Healthy Ageing, which is financially supported by the Netherlands Genomics Initiative
(project number 050-060-810).
Financial support for this thesis by the Netherlands Consortium for Healthy Ageing
and Philips Healthcare is gratefully acknowledged.
Prof. Dr. R.G.J. Westendorp
Dr. S.P. Mooijaart
Women sit, or move to and fro – some old, some young;
Overige leden
The young are beautiful – but the old are more beautiful than the young.
Dr. ir. D. van Heemst
Prof. N. Sattar (University of Glasgow, UK)
Prof. A. Bartke ( Southern Illinois University School of Medicine, Springfield, USA)
(Walt Whitman (1819–1892). Leaves of Grass. 1900)
Chapter 1. Introduction and outline of thesis
Part 1. Glucose metabolism in human longevity and old age
Chapter 2. Familial longevity is marked by enhanced insulin sensitivity 17
Chapter 3. Proton magnetic resonance spectroscopy shows lower 37
intramyocellular lipid accumulation in middle-aged subjects
predisposed to familial longevity.
Chapter 4. Responsiveness of the innate immune system and glucose
concentrations in the oldest old
Chapter 5. Ambulant 24-hour glucose rhythms mark calendar and
biological age in apparently healthy individuals
Part 2. Improving glucose metabolism in an ageing population
Chapter 6. Effects of a web-based intervention on physical activity and
metabolism in older adults; randomized controlled trial.
Chapter 7. Dose response effects of a Web-based physical activity program 107
on body composition and metabolic health in inactive older
adults: additional analyses of a randomized controlled trial
Chapter 8. Perspectives125
Chapter 9. Nederlandse samenvatting131
List of publications
Curriculum Vitae144