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Potent and selective FXIIIa inhibitor!
_____________________________________________________ transglutaminase newsletter July-2014
ZED1301: potent direct acting FXIIIa inhibitor now commercially available!
 Strong inhibitor of coagulation factor XIII (IC50 ~ 100 nM)
 Substantial selectivity against TG2 (30-fold, IC50 ~ 3,000 nM)
 EC50 in thromboelastometry, whole human blood ~ 30 µM
 Used to solve the crystal structure of FXIII in the active conformation
(Stieler, M. et al. Angewandte Chemie Intl. Ed. 2013, 52, 11930)
ZED1301 (product number A108) is a peptidic inhibitor containing an electrophilic Michael
acceptor (MA) warhead. The structure/sequence Ac-D-MA-Nle-Nle-LPWP-OH
(Nle, norleucine) provides both potency and selectivity in biochemical and in vitro whole blood
assays. So far, pharmacokinetic data are not available.
Within our drug development program we developed novel proprietary FXIIIa inhibitors suitable for
in vivo animal studies. Please contact us ([email protected]) for further information.
Find below the bestsellers out of our inhibitor toolbox frequently used.
Art. No. Name
Unit
Price
5 mg
480 €
A108
Ac-D-MA-Nle-Nle-LPWP-OH, "ZED1301"
Z006
Z-DON-Val-Pro-Leu-OMe, "Z-DON"
10 mg
385 €
B003
Boc-DON-Gln-Ile-Val-OMe, "Boc-DON"
10 mg
385 €
T101
1,3,4,5-Tetramethyl-2[(2-oxo-propyl)thio] imidazolium chloride
10 mg
480 €
D003
1,3-Dimethyl-2[(2-oxo-propyl)thio]imidazolium chloride
100 mg
480 €
New products, just launched: Fibrin glue (porcine and bovine)
Fibrin Glue is a natural product consisting of two components: fibrinogen concentrate and
thrombin. After mixing both components, polymerization leads to an elastic fibrin matrix.
Art. No. Name
Unit
Price
F007
Fibrin Glue (porcine)
1 Kit
195 €
F008
Fibrin Glue (bovine)
1 Kit
195 €
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For detailed information concerning our products please refer to our web site: www.zedira.com.
Should you have any questions or queries about our products, please do not hesitate to contact us: [email protected]
We are constantly enlarging our product portfolio in order to fulfill researchers’ requirements in the field of transglutaminase.
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Zedira GmbH
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64293 Darmstadt
Germany
Phone:
+49 6151 3251-00
Fax:
+49 6151 3251-19
Web:
www.zedira.com
E-mail:
[email protected]
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