Feb. 26, 2014 - University of Guelph

Department of Molecular and Cellular Biology
View 2014 schedule at www.uoguelph.ca/mcb
Wednesday, February 26, 2014
at 1:30 p.m. in MACK 120
“Nod proteins in immunity and infection”
Dr. Dana Philpott
Dept. of Immunology, University of Toronto
Faculty Host: Dr. Emma Allen-Vercoe
Our group studies a family of innate immune receptors called the Nod-like receptors (NLRs).
These proteins represent an intracellular surveillance system for detecting microbial and hostderived danger signals. In particular, we study Nod1 and Nod2, which detect peptidoglycan
(PG) from the bacterial cell wall and trigger inflammation. Detection of these PG by Nod1 and
Nod2 triggers a signal transduction cascade that culminates in the activation of NFκB and the
production of pro-inflammatory mediators. Moreover, Nod triggering can regulate autophagy.
Importantly, Nod1 and Nod2 have been implicated in inflammatory bowel disease (IBD), in
particular Nod2 has been associated with Crohn’s disease, yet a clear understanding of how
dysfunctional Nod activation leads to aberrant inflammation is still lacking. ATG16L1 is a
protein involved in autophagy and has also been linked to Crohn’s disease. We showed
previously that Nod1 and Nod2 interact with ATG16L1 and this association promotes
autophagy of intracellular bacteria. Since Nod1 and Nod2 are important for triggering
bacterial-induced autophagy, and autophagy can influence the immune response, our current
work aims to examine how autophagy might regulate the cytokine response to infection and
Nod1 or Nod2 stimulation.
Coffee,Tea & Timbits
A great opportunity to hear
leading researchers in the scientific
community discuss their work!
All Welcome to Attend