Proc. Intl. Soc. Mag. Reson. Med. 22 (2014)

The Performance of NODDI Estimation Using a Common 2-Shell Protocol
Zhen Wang1, Yuan Wang1, Jianye Zhang1, Xu Yan2, Hui Liu2, and Zeping Xiao1
Shanghai Mental Health Center, Shanghai, China, 2MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China
The neurite orientation dispersion and density imaging (NODDI) is a new model proposed recently to detecting microstructure changes of the
brain [1]. It acquires a two-shell acquisition protocol to accurately calculate its indices. Optimized protocols were evaluated to shorten its acquisition
time. The optimized protocols sample the higher b-value at twice the angular resolution of the lower b-value because of higher signal variation at high
b-value. Although the optimized protocol achieved a good balance of acquisition time and image quality, its special gradient table setting cannot be
directly configured on a commercial scanner, and required specific experience. In contrast, another multi-b-value diffusion model, diffusion kurtosis
imaging (DKI) [2], normally adopts a common 2-shell protocol [3] with the same gradient direction setting in each shell and is available on most
commercial scanners. Because of this simplicity, DKI has been widely applied in a large number of clinical studies so far. Thus, in this paper, we
evaluate the feasibility to do NODDI estimation using a common 2-shell protocol,
which may greatly facilitate the application of the NODDI model.
Brain diffusion datasets were collected from one healthy volunteer using a 3.0T
system (Magnetom Verio, Siemens AG, Erlangen, Germany). Two different 2-shell
diffusion protocols were adopted: an optimized NODDI protocol with 21 and 42
gradient directions at b = 700 and 2000 s/mm2, respectively; a 2-shell protocol with 30
gradient directions at both b = 1000 and 2000 s/mm2. The NODDI toolbox [2] was
used to estimate NODDI indices: intra-cellular volume fraction (ICVF), isotropic
volume fraction (IVF) and orientation dispersion index (ODI). Two regions of interest
(ROI) were drawn in gray matter and white matter, respectively, and mean indices
values from two protocols were compared. In addition, the joint histogram of the
indices from 2 protocols were created, and correlation of the indices were also
evaluated using a linear fitting with the formula “Y = K · X”, where X, Y are indices
of 2 protocols, and K is the rate of two indices.
Figure 1. The indices of NODDI estimated using an optimized
NODDI protocol and a common 2-shell protocol.
The result showed that two protocols generated
comparable NODDI indices maps (Figure 1). The IVF and
ODI maps of two protocols look very similar, and have closed
mean value in both white matter and gray matter, with
differences less than 3% (Figure 2). Although the visual
appearance of the ICVF map using an optimized protocol
looks smoother than the common one in the white-matter
region, the ROI mean did not showed any significant
difference. Furthermore, the correlation of the indices from 2
protocols was very high (Figure 2). In the linear fitting, the
rate and root mean square error were at 0.9926, 0.08116 for
ICVF, 0.9974, 0.08929 for IVF, 0.9969, 0.1022 for ODI.
The common 2-shell protocol was shown to be a good
replacement of the optimized protocol with equivalent image
quality and more convenience. On one side, the common
protocol is easy to implement, thus can be widely adopted. On
the other side, many other diffusion methods, such as DKI, biFigure 2. Comparison of NODDI indices using optimized and common protocols. In upper
exponential model, uses common multi-shell protocols, and
row, two ROIs in white matter and gray matter were drawn, and no significant differences
were widely applied in studies of brain development or neural
were found between two protocols. In lower row, joint histogram was drawn, the indices
disease. Thus the value of NODDI in other multi-b-value
of two protocols showed high linear correlation.
diffusion studies can be preliminarily evaluated without
reacquiring clinical data, but using acquired data of other multi-b-value models. Moreover, NODDI, as a new and powerful diffusion model, provides
unique and specific structural information of neurite. Thus, the comparison between NODDI and other multi-b-value diffusion models is also an
interesting topic, and can also be easily conducted in the future.
Acknowledgement: This study is supported by a grant from Science and Technology Commission of Shanghai Municipality (Grant No. 24119a8601)
References: [1] Zhang H et al. Neuroimage. 2012. [2]Jensen et al., MRM. 2005. 61(4):1000-16. [3] Jensen et al. ISMRM 2009.
Proc. Intl. Soc. Mag. Reson. Med. 22 (2014)