Dr. Ruchuan Liu

Ruchuan Liu, PhD
Dr. Ruchuan Liu
PI and PhD Supervisor
College of Physics, Chongqing University
Visiting Associate Professor
National University of Singapore
Email: [email protected], [email protected]
1999-2004 Ph.D. Physical Chemistry, Columbia University
1994-1999 Ph.D. Condensed Matter Physics, the University of Science &
Technology of China (USTC)
1990-1994 B.S. Materials Physics, USTC
Professional experience:
2013“100 Talent Plan” PI, College of Physics, Chongqing
University, Chongqing, China
2013Visiting Associate Professor, Department of Physics, National
University of Singapore, Singapore
Assistant Professor, Department of Physics, National
University of Singapore, Singapore
Principal Investigator, MechanoBiology Institute, National
University of Singapore, Singapore
Postdoctoral Research Fellow, Department of Biological
Science, Columbia University, USA
Postdoctoral Research Fellow, Fundamental Science Division,
Pacific Northwest National Laboratory, USA
Research Interests:
The improvements and applications of multi-functional biomaterials,
nano/molecular devices and solar cell materials. Cellular signaling processes
and protein-protein interactions. We are also doing theoretical calculation
and molecular dynamic simulations related to above topics.
Research Projects
1. Single-molecule tracking of synthetic molecular motors,50k RMB,
20132. 100-talents plan startup grant,2m RMB,20133. The Elasticity and Homophilic Interactions of Extracellular Domain of
Ruchuan Liu, PhD
Cadherins -- A Study by Single-Molecule Experiments,Singapore MBI
project,900k SGD,2009-2012
4. From Bio Mimicking to Ultra and Multi Functional Bio Composite
Materials,National University of Singapore seed grant, 2010
5. Single-Molecule Fluorescence / Force Spectroscopy of Green
Fluorescent Protein,National University of Singapore Tier 1 grant,180k
6. Single-Molecule Force Spectroscopy of Interaction between Calmodulin
and Peptids,National University of Singapore startup grant,180k SGD,
“Force-dependent conformational switch of -catenin controls vinculin binding”, M.
Yao, W. Qiu, R. Liu, A. K. Efremov, P. Cong, R. Seddiki, M. Payre, C. T. Lim, B. Ladoux,
R. Mège, J. Yan, Nature Communications, 5, 4525 (2014)
2) “Stretch response of p130Cas depends on the flexibility of the non-globular substrate
domain, and does not require actomyosin contractility”, K. Hotta, S. Ranganathan, R.
Liu, F. Wu, H. Machiyama, R. Gao, M. M. Kanchi, K. Ohe, C.-Y. Kim, Y. Sawada, PLOS
Computational Biology, 10, e1003532 (2014) doi:10.1371/journal.pcbi.1003532
3) “Hybrid Organic/Inorganic Nanocomposites for Photovoltaic Cells”, *R. Liu, Materials,
7, 2747 (2014) doi:10.3390/ma7042747
4) “P130Cas Substrate Domain is Intrinsically Disordered as Characterized by
Single-Molecule Force Measurements”, C. Lu, F. Wu, W. Qiu, and *R. Liu, Biophysical
Chemistry, 180, 37 (2013)
5) “Bipedal Nanowalker by Pure Physical Mechanisms”, J. Cheng, S. Sreelatha, R. Hou, A.
Efremov, R. Liu, J. RC van der Maarel, Z. Wang, Phys. Rev. Lett.,109, 238104 (2012)
6) “Remarkable Disparity in Mechanical Response among Extracellular Domains of Type
I and II Cadherins”, *R. Liu, F. Wu, J.P. Thiery, Journal of Biomolecular Structures and
Dynamics, 31, 1137 (2013)
7) “Force Transduction at Adhesion Sites by Stretching Single Talin Rod Molecules: A
Molecular Mechanism for Vinculin Recruitment”, A. del Rio, R. Perez-Jimenez, R. Liu,
P. Roca-Cusachs, J. M. Fernandez and M. P. Sheetz, Science 323, 638-641 (2009)
8) “Mechanical characterization of Protein L in the low-force regime by electromagnetic
tweezers/evanescent nanometry”, *R. Liu, S. Garcia-Manyes, A. Sarkar, C. L. Badilla and
J. M. Fernandez, Biophysical Journal 96(9), 3810-3821 (2009)
9) “Imaging of photoinduced interfacial charge separation in conjugated polymer/
semiconductor nanocomposites”, *R. Liu, J. Phys. Chem. C 113 (21), 9368-9374 (2009)
10) “Fluctuating Two-State Light Harvesting in a Photosynthetic Membrane”, D. Pan, D.
Hu, R. Liu, X. Zeng, S. Kaplan, H. P. Lu, J. Phys. Chem. C 111 (25), 8948-8956 (2007)
11) “Revealing Two-State Protein-Protein Interactions of Calmodulin by Single-Molecule
Spectroscopy”, R. Liu, D. Hu, X. Tan, H. P. Lu, J. Am. Chem. Soc. 128(31), 10034-10042
Ruchuan Liu, PhD
12) “A Conformational Switch of Intramolecular Electron Transfer”, M. W. Holman, P.
Yan, K.-C. Ching, R. Liu, F. I. Ishak, D. M. Adams. Chem. Phys. Lett. 413(4-6), 501-505,
13) “Studying and Switching Electron Transfer: From the Ensemble to the Single
Molecule”, M.W. Holman, R. Liu, L. Zang, P. Yan, S.A. Dibenedetto, R.D. Bowers, D. M.
Adams, J. Am. Chem. Soc. 126(49), 16126-16133 (2004)
14) “Single-Molecule Spectroscopy of Interfacial Electron Transfer”, M.W. Holman, R. Liu,
D.M. Adams, J. Am. Chem. Soc. 125(41), 12649-54, (2003).
15) “Single-Molecule Spectroscopy of Intramolecular Electron Transfer in
Donor-Bridge-Acceptor Systems”, R. Liu, M.W. Holman, L. Zang, D.M. Adams, J, Phys.
Chem. A 107(34), 6522-6526, (2003).
16) “A Single-Molecule Probe Based on Intramolecular Electron Transfer”, L. Zang, R.
Liu, M.W. Holman, K. T. Nguyen, D.M. Adams, J. Am. Chem. Soc. 124(36), 10640-10641
17) “Edge Transfer Lithography of Molecular and Nanoparticle Materials”, O.
Cherniavskaya, A. Adzic, C. Knutson, B.J. Gross, L. Zang, R. Liu, D.M. Adams, Langmuir
18(18), 7029-7034, (2002).
Students’ training:
Supervise “National College Student Creation Program”
Supervise a student team for “College Physics Match” and
rank No. 1
Professor Julio Fernandez, Columbia University, USA
Professor Louis Brus, Columbia University, USA
Professor Peter Lu, Bowling Green State University, USA,
Professor Ling Zang, Southern Illinois University, USA,
We welcome outstanding postdoctoral/postgraduate applications from
talented, motivated individuals. Please email to [email protected] or
[email protected] Dr. Liu also welcome interested students to visit the lab
and to talk with him as well.