Tips Newsletter - Access Technologies

Vascular Access Catheter TipS
sharing information to improve long - term vascular access
Summer 2014
To our Valued Customers,
We want to thank you for your continued business and let you know that we have completed the acquisition of the Solomon Scientific port,
catheter and needle product lines. The complimentary product offerings and strong strategic fit is in line with our strategy to build a broader
portfolio of products to support pre-clinical research. If you have any questions, please don’t hesitate to give me a call.
Cheers & best wishes. Pam
[email protected]
making news ....
THE FUNNELCATH - tapered during the extrusion process
....provides a very small distal catheter tip for intravascular placement in rodents
while providing a way to connect these catheters to an infusion source requiring
a large ID - an access port, luer stub adaptor or pump.
1.2 french distal tip
3 french proximal end
proximal segment
distal segment
making news ....
HYDROMER COATING - the environmentally friendly surface
....a highly lubricious, non-eluting surface coating for the reduction of biofilm adhesion and bacterial colonzation.
Hydromer, a biocompatible, hydrophilic medical coatings
swells instantaneously upon contact with water-containing
fluids to form a waxy surface texture that is highly lubricious.
The highly lubricious surface allows the catheter to slide
easily through the vessel improving the ease of delivery
of catheters through the difficult vascular pathways. The
slippery surface of the Hydrocoated polyurethane catheter
exhibits significant antithrombogenic behaviour in the
vascular environment by reducing biofilm adhesion and
bacterial colonization.
Hydromer coated catheter in the right
Uncoated catheter in the left femoral artery
femoral artery of a dog, showing no vessel
thickening, and no clot formation
of a dog, showing vessel thickening and clot
Drug testing using animals became important in the
Summer 2014
Access “TipS”
twentieth century with the passing of the 1938 Federal
is published by:
Food, Drug and Cosmetic Act. The regulation was as a
result of the “ Taste of Raspberries, Taste of Death” 1937
tel. 847-674-7131
Elixir Sulfanilamide Incident, required safety testing of
fax. 847-674-7066
toll free (USA) 877-674-7131
drugs on animals before they could be markeded. Kathleen
[email protected]
Hobson was eight years old when her mother unknowingly
dosed her with poisonous cough syrup. As FDA scientists
would quickly realize, the syrup was lethal because it was
sweetened by a compound known as diethylene glycol which kills by causing acute kidney damage. the 1938 act was the first major
upgrade of 1906 legislation. This law established the U.S. Government as a guardian of the American people’s safety was in many ways
a piece of regulatory lace full of exemptions and exceptions. The new law filled many of the holes.
Vascular Access Catheter TipS
sharing information to improve long - term vascular access
Summer 2014
a continuing controversy - where is the
Central venous cannulation is currently an indispensable technique and with this comes the continuing debate among physicians,
veterinarians, nurses, and federal regulatory agencies regarding the correct position for the tip of a central venous catheter.
The traditional approach, for this underappreciated criterion, has been to place the catheter tip in the distal third of the
superior vena cava, a location thought to minimize complications such as catheter migration, extravasation of irritant
agents, vascular perforation, local vein thrombosis, catheter malfunction and cranial retrograde injection. While some
believe that the performance and durability of the catheter will be improved by positioning the catheter tip within the
upper right atrium, in veterinary medicine the position for the tip of a jugular venous catheter is described as caudal
to the first rib and cranial to the right atrium.
While the exact location is subject to discussion, the concensus is that three criteria need to be met to provide an optimal environment
and continued function; they are.....
- the tip should be in an area of high blood flow to provide dilution of the infusate
- the tip should lie parallel to the vessel wall so that it is free floating within the vessel to minimize irritation of the vessel wall
- the tip should be in an area where the contraction of the atria provide pulsatiltiy and turbulance that prevents stagnation of blood
Why Does The Catheter Tip Is Location Matter?
...because one of the frustrations encountered is the apparent
‘failure’ of the catheter & the question....
Why can I infuse but not withdraw?
2 of the most common reasons are..............
Incorrect positioning of the catheter tip - the
catheter may be in a position that results in the
tip abutting against the vessel wall, thereby resulting in a partial
occlusion due to malposition. The catheter functions for infusion,
but when aspiration is attempted negative pressure “pulls” the
tip of the catheter up against the vessel wall preventing inflow.
Optimal catheter tip location in a large vessel or at the right atrial
- vena cava junction generally reduces this complication.
Thrombus formation at the catheter tip - the catheter tip is
probably rubbing the endothelial lining of the vessel creating
irritation and platelet aggregation. No secret why blood return
is difficult to establish, since constant tip irritation leads to fibrin
formation and consequently a PWO.
Good Reads
you may have missed
Bussey CT. et. al. (2014) “Dual implantation of a radio-telemeter
and vascular access port allows repeated hemodynamic and
pharmacological measures in conscious lean and obese rats.”
Lab Anim 2;48(3):250-60.
Farrow HA. et. al. (2013) “Jugular vascular access port implantation
for frequent, long-term blood sampling in cats: methodology,
assessment, and comparison with jugular catheters.”
Res Vet Sci 95(2):681-6
Why Does The Catheter Diameter Matter?
.....what determines the fow rate thought the catheter?
Why not use a catheter with a larger inner diameter?
The optimal proportion between the catheter diameter and
vessel diamter is a balancing act and relates to one of the pillars
of Virchow’s triad - Stasis. It is presumed that the presence of a
catheter within the lumen of a vein will decrease blood flow and
potentially create venous stasis. This being the case, the outer
diameter of the catheter versus the inner diameter of the vein
therefore may have significant impact on patency. Catheter size
selection may in fact be a controllable patency risk factor.
Although some clinical studies have shown a statistically signifi
cant increase in thrombosis with larger versus smaller catheters,
the degree to which a given catheter impacts flow has not been
described. General guidelines recommend that the target vien
must be able to “accomodate the catheter”, but I have not found
any specific size guidelines. If you have any information on this
subject, please will you share it. There is an interesting paper on
this subject by Nifong T., McDevitt T. “The Effect of Catheter
to Vein Ratio on Blood Flow Rates in a Simulated Model of
Peripherally Inserted Central Venous Catheters” (Chest 2011;
140;48-53). We do haave copies available if you are interested
in learning more.
How large a catheter is too large?
Our hypothesis is:
When the catheter takes up over 3% of the total area of
the vessel, occlusion due to stasis is more likly to occur.
what’s making
at Access Technologies
Access Technologies Acquires Solomon Scientific Product Lines
All the Solomon products will be maintained, supported and manufactured in our FDA registered and ISO 13485
certified facility in Chicago, Illinois and will allow Access Technologies to offer an expanded line of products for all
species and access targets. If you have any questions about any of the Access Technologies or Solomon Scientific
products please let us know.
Rodent Catheter design
the importance of the retention bead
Designed in colaboration with leading researchers, and manufactured
from medical grade polyurethane and silicone. These rodent catheters
feature both vessel and subcutaneous retention beads, a rounded tip
and are packaged with a stainless steel plug and Luer stub adaptor.
All catheters ship sterile - EtO exposed.
Skin Suture
Retention Beads
Rodent Arterial Catheter
with moveable vessel &
skin retention beads
If necessary, our standard catheters can be modified to suit your
Call to enroll in our validation program where you can receive up to
ten rodent catheters of your choice for an in-house evaluation study.
LoVol™ Port design
the ultra-low dead volume port
for CSF infusion and withdrawal
The ultra-low dead volue of the LoVol™ ports facilitates enhanced CSF (cerebrospinal
fluid) collection and is perfect for any application requiring minimal dead volume,
i.e., unusually expensive test article studies. The dead space in the LoVol is reduced
by about 90% compared to that of traditional ports.
a division of Access Technologies
LoVol Port Chamber
dead volume 15μL
Conventional Port Chamber
dead volume 130μL
Tel: 847.674.7131 • Toll Free USA: 877.674.7131 • Fax: 847.674.7066 • E-mail: [email protected]