原著論文 ~2012 (*corresponding author)
1) Kamezaki C, Nakashima A, Yamada A, Uenishi S, Ishibashi H, Shibuya N, Hama S,
Hosoi S, Yamashita E *Kogure K. Synergistic antioxidative effect of astaxanthin
and tocotrienol by co-encapsulated in liposomes. J. Clin. Biochem. Nutr. in press.
2) Itakura S, *Hama S, Matsui R, Kogure K. Effective cytoplasmic release of siRNA
from liposomal carriers by controlling the electrostatic interaction of siRNA with a
charge-invertible peptide, in response to cytoplasmic pH. Nanoscale 8, 1064910658 (2016).
3) Hasan M, Nishimoto A, Ohgita T, Hama S, Kashida H, Asanuma H, *Kogure K.
Faint electric treatment-induced rapid and efficient delivery of extraneous
hydrophilic molecules into the cytoplasm. J. Control. Release 228, 20-25 (2016).
4) Takagi K, Ohgita T*, Yamamoto T, Shinohara Y, Kogure K. Transmission of
external environmental pH information to the inside of liposomes via pore-forming
proteins embedded within the liposomal membrane. Chem. Pharm. Bull. 64, 432438 (2016).
5) Yamada A, Mitsueda A, Hasan M, Ueda M, Hama S, Warashina S, Nakamura T,
Harashima H, *Kogure K. Tri-membrane nanoparticles produced by combining
liposome fusion and a novel patchwork of bicelles to overcome endosomal and
nuclear membrane barriers to cargo delivery. Biomat. Sci. 4, 439-447 (2016).
6) Yamashita R, Tabata Y, Iga E, Nakao M, Sano S, Kogure K, Tokumura A, *Tanaka
T. Analysis of molecular species profiles of ceramide-1-phosphate and
sphingomyelin using MALDI-TOF mass spectrometry. Lipids 51, 263-270 (2016).
7) Hama S, Itakura S, Nakai M, Nakayama K, Morimoto S, Suzuki S, *Kogure K.
Overcoming the polyethylene glycol dilemma via pathological environmentsensitive change of the surface property of nanoparticles for cellular entry. J.
Control. Release 206, 67-74 (2015).
8) Toyoda M, Hama S, Ikeda Y, Nagasaki Y, *Kogure K. Anti-cancer vaccination by
transdermal delivery of antigen peptide-loaded nanogels via iontophoresis. Int. J.
Pharm. 483, 110-114 (2015).
9) Itakura S, Hama S, Ikeda H, Mitsuhashi N, Majima E, *Kogure K. Effective
capture of proteins inside living cells by antibodies indirectly linked to a novel cellpenetrating polymer-modified protein A derivative. FEBS J. 282, 142-152 (2015).
10) Nakamura I, *Hama S, Itakura S, Takasaki I, Nishi T, Tabuchi Y, Kogure K.
Lipocalin2 as a plasma marker for tumors with hypoxic regions. Sci. Rep. 4, 7235
11) Itakura S, Hama S, Ohgita T, *Kogure K. Development of nanoparticles
incorporating a novel liposomal membrane destabilization peptide for efficient
release of cargos into cancer cells. PLOS ONE 9, e111181 (2014).
12) Nakamura T, Ono K, Suzuki Y, Moriguchi R, Kogure K, *Harashima H.
Octaarginine-modified liposomes enhance cross-presentation by promoting the Cterminal trimming of antigen peptide. Mol. Pharm. 11, 2787-2795 (2014).
13) Ikeda Y, Tsuchiya H, Hama S, Kajimoto K, *Kogure K. Resistin regulates the
expression of plasminogen activator inhibitor-1 in 3T3-L1 adipocytes. Biochem.
Biophys. Res. Commun. 448, 129-133 (2014).
14) Hama S, Kimura Y, Mikami A, Shiota K, Toyoda M, Tamura A, Nagasaki Y,
Kanamura K, Kajimoto K, *Kogure K. Electric stimulus opens intercellular spaces
in skin. J. Biol. Chem. 289, 2450-2456 (2014).
15) Ohgita T, Hayashi N, Gotoh N, *Kogure K. Suppression of type III effector
secretion by polymers. Open Biol. 3, 130133 (2013).
16) IkedaY, Tsuchiya H, Hama S, Kajimoto K, *Kogure K. Resistin affects lipid
metabolism during adipocyte maturation of 3T3-L1 cells. FEBS J. 280, 5884-5895
17) Kawahara A, Haraguchi N, Tsuchiya H, Ikeda Y, Hama S, *Kogure K. Peroxisome
proliferator-activated receptor(PPAR)γ-independent specific cytotoxicity against
immature adipocytes induced by PPARγ antagonist T0070907. Biol. Pharm. Bull.
36, 1428-1434 (2013).
18) Mitsueda A, Shimatani Y, Ito M, Ohgita T, Yamada A, Hama S, Gräslund A,
Lindberg S, Langel U, Harashima H, Nakase I, Futaki S, *Kogure K. Development
of a Novel Nanoparticle by Dual Modification with the Pluripotential CellPenetrating Peptide PepFect6 for Cellular Uptake, Endosomal Escape and
Decondensation of an siRNA Core Complex. Biopolymers (Peptide Sci.) 100, 698704 (2013).
19) Tsukamoto T, Hama S, Kogure K, *Tsuchiya H. Selenate induces epithelialmesenchymal transition in a colorectal carcinoma cell line by AKT activation. Exp.
Cell Res. 319, 1913–1921 (2013).
20) Ebata Y, Takino J, *Tsuchiya H, Sakabe T, Ikeda Y, Hama S, Kogure K, Takeuchi
M, Shiota G. Presence of glyceraldehyde-derived advanced glycation end-products
in the liver of insulin-resistant mice. Int. J. Vitamin Nutr. Res. 83, 137–141
21) Ohgita T, Hayashi N, Hama S, Tsuchiya H, Gotoh N, *Kogure K. A novel effector
secretion mechanism based on proton-motive force dependent type III secretion
apparatus rotation. FASEB J. 27 (2013) 2862-2872.
22) Nakamura T, Moriguchi R, Kogure K, *Harashima H. Incorporation of polyinosinepolycytidylic acid enhances cytotoxic T cell activity and antitumor effects by
octaarginine-modified liposomes encapsulating antigen, but not by octaargininemodified antigen complex. Int. J. Pharm. 441, 476-481 (2013).
23) Yoshikawa O, Ebata Y, *Tsuchiya H, Kawahara A, Kojima C, Ikeda Y, Hama S,
Kogure K, Shudo K, Shiota G. A retinoic acid receptor agonist tamibarotene
suppresses iron accumulation in the liver. Obesity (Silver Spring). 21, E22-E25
24) *Tsuchiya H, Ebata Y, Sakabe T, Hama S, Kogure K, Shiota G. High-fat, highfructose induces hepatic iron overload via a hepcidin-independent mechanism prior
to the onset of liver steatosis and insulin resistance in mice. Metabolism 62, 62-69
25) Hama S, Uenishi S, Yamada A, Ohgita T, Tsuchiya H, Yamashita E, *Kogure K.
Scavenging of Hydroxyl Radicals in Aqueous Solution by Astaxanthin Encapsulated
in Liposomes. Biol. Pharm. Bull. 35, 2238-2242 (2012).
26) *Tsuchiya H, Ikeda Y, Ebata Y, Kojima C, Katsuma R, Tsuruyama T, Sakabe T,
Shomori K, Komeda N, Oshiro S, Okamoto H, Takubo K, Hama S, Shudo K,
Kogure K, Shiota G. Retinoids ameliorate insulin resistance in a leptin-dependent
manner in mice. Hepatology. 56, 1319-1330 (2012).
27) Kitazoe K, Park Y S, Kaji N, Okamoto Y, Tokeshi M, Kogure K, Harashima H,
*Baba Y. Fabrication of functionalized multifunctional envelope-type nanodevices
using a chaotic mixer array in a microfluidic chip. PLoS One 7, e39057 (2012).
28) Hama S, Utsumi S, Fukuda Y, Nakayama K, Okamura Y, Tsuchiya H, Fukuzawa K,
Harashima H, *Kogure K. Development of a Novel Drug Delivery System
consisting of an Antitumor Agent Tocopheryl Succinate. J. Control. Release 161,
843-851 (2012).
29) Hama S, Takahashi K, Inai Y, Shiota K, Sakamoto R, Yamada A, Tsuchiya H,
Kanamura K, Yamashita E, *Kogure K. Protective Effects of Topical Application of
a Poorly Soluble Antioxidant Astaxanthin Liposomal Formulation on UV-induced
Skin Damage. J. Pharm. Sci. 101, 2909-2916 (2012)
30) Hama S, Arata M, Nakamura I, Kasetani T, Itakura S, Tsuchiya S, Yoshiki T,
*Kogure K. Prevention of Tumor Growth by Needle-free Jet Injection of antiC7orf24 siRNA. Cancer Gene Ther. 19, 553-557 (2012).
31) Kigasawa K, Miyashita M, Kajimoto K, Kanamura K, Harashima H, *Kogure K.
Efficient intradermal delivery of superoxide dismutase using a combination of
liposomes and iontophoresis for protection against UV-induced skin damage. Biol.
Pharm. Bull. 35, 781-785 (2012).
1) 喜田孝史、木村朱里、伊藤 葵、山下量平、小暮健太朗、徳村 彰、*田中
セラミド-1-リン酸.脂質栄養学 25, 75-85 (2016).
(*corresponding author)
1) Hama S, *Kogure K. Nanoparticles consisting of tocopheryl succinate are a novel
drug-delivery system with multifaceted antitumor activity. Biol Pharm Bull. 37, 196200 (2014).
2) Nakase I, Akita H, Kogure K, Gräslund A, Langel U, Harashima H, *Futaki S.
Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using CellPenetrating Peptides. Acc Chem Res. 45, 1132-1139 (2012).
1) *小暮健太朗、濵
浸透メカニズム.「Cosmetic Stage」10, pp1-6 (2015).
2) 濱 進,*小暮健太朗. 腫瘍環境応答性素子と脂質膜との相互作用を利用した
DDS の創製.MEMBRANE, 39, 277-282 (2014).
3) 濱 進,福澤健治,*小暮健太朗. ビタミン E 誘導体によるがん細胞特異的作
用とがん治療への展開.ビタミン, 2, 83-91 (2014).
4) 池田義人、*小暮健太朗.脂肪細胞に対する siRNA 導入によるアディポカイ
Antisence 18, 21-34 (2014).
5) 松尾保孝、加地範匡、畠山浩人、渡慶次学、小暮健太朗、馬場嘉信、*原島秀
吉.Nano Packaging が拓く次世代核酸医薬医療.表面.51, 227-240 (2013).
6) 梶本和昭、兵藤守、小暮健太朗、*原島秀吉.DDS 技術による遺伝子・核酸
医薬の将来.月刊ファインケミカル 特集 先端医療実用化のための最新 DDS
技術の動向(シーエムシー出版)41, 31-36, (2012).
著書 ~2012 (*corresponding author)
1) *Kogure K, Hama S.: Nanomaterials for cosmetics. In Encyclopedia of Polymeric
Nanomaterials. Edit. by Kobayashi S & Müllen K. Springer. pp1-4 (2014).
1) *小暮健太朗、気賀澤郁、濱 進、梶本和昭.第2章第1節イオントフォレ
シスによる経皮デリバリー技術. 「注射剤・経口製剤に代わる新しい薬剤
投与デバイスの開発」(株)技術情報協会 pp49-52 (2014).
2) *小暮健太朗、濱 進、梶本和昭. イオントフォレシスによる機能性物質の
皮内デリバリー. 「機能性化粧品と薬剤のデリバリー」(杉林堅次、正木
仁、市橋正次監修)シーエムシー出版 pp 121-125 (2013).
3) 小暮健太朗、*原島秀吉.第 11 章人工遺伝子デリバリーシステム MEND に
よる毛孔内への BMPR1A 遺伝子の送達.「毛髪再生の最前線」(前田憲寿監
修)シーエムシー出版 pp101-107(2013).
4) *小暮健太朗、気賀澤郁、濱 進、梶本和昭.第 4 章第 1 節[4]<3>バイオ・
生物製剤の非侵襲的な経皮 DDS 技術.「DDS 製剤の開発・評価と実用化手
法」㈱技術情報協会 pp210-214(2013).
5) 濱 進、*小暮健太朗.第 4 章 pH 応答性の薬物キャリア.遺伝子医学
MOOK 別冊「ここまで広がるドラッグ徐放技術の最前線.古くて新しいド
ドゥ pp357-362 (2013).
6) *小暮健太朗、濱 進、梶本和昭.第 6 章 2 項イオントフォレシスによる機
次、正木仁、市橋正光監修)シーエムシー出版 pp121-125(2012).
7) 小暮健太朗、林泰弘、*原島秀吉. 第3章 DDS 用バイオマテリアル第5節
多機能性エンベロープ型ナノ構造体による遺伝子デリバリー. 先端バイオ
pp364-369 (2012).
8) *小暮健太朗、濱 進、梶本和昭.第 3 章 4 項新しいコンセプトに基づくペ
(木曽良明、向井秀仁 監
修)シーエムシー出版 pp136-140 (2012).
進、*小暮健太朗.第 2 章 4 項アスタキサンチンのラジカル消去活性.
「アスタキサンチンの機能と応用」(吉川敏一、内藤祐二 監修)シーエム
シー出版 pp48-51 (2012).
9) 濱